In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6086-21-1 as follows. 6086-21-1
(a) To a solution of 19.6 g (0.236 mol) of 1-methyl-1,2,4-triazole in 350 ml of ether at -78¡ã C. under argon was added n-butyllithium (91 ml, 0.236 mol, 2.5M in hexane) within a 30 min period and the mixture was stirred at -78¡ã C. for 2 h, and followed with the addition of 17.3 g (0.236 mol) of DMF in 45 ml of ether. The mixture was slowly warmed to 0¡ã C., and was stirred at 0¡ã C. for 2 hours, then 25 g of silica gel was added to the mixture. The whole suspension was packed on a silica column with methylene chloride and the eluent (methylene chloride/ether, 4:1) was concentrated to afford 17.75 g (67.7percent) of 1-methyl-1,2,4-triazolyl-5-carboxaldehyde, as a yellow oil.
According to the analysis of related databases, 6086-21-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sterling Winthrop Inc.; US5569655; (1996); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics