Application of 1455-77-2, A common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Then, an amidation step is carried out, the reaction equation being as follows: The 1.49g (15mmol, 1eq) of the compound of Formula III-1 3,5-amino-1,2,4-triazole, 3.64 g (36 mmol, 2.4 eq) of triethylamine were dissolved in 50 mL of dichloromethane,50 mL of a dichloromethane solution containing 9.39 g of the compound shown by the formula 11-1 (4- (4′-nitrophenyl) benzoyl chloride) was slowly added dropwise at 0 ¡ã C. After completion of the dropwise addition,The reaction solution was allowed to react at room temperature for 24 h,Subsequently, the reaction solution was washed with 200 mL of pure water, After the layers were separated, the organic phase was washed twice with saturated sodium carbonate solution and then dried over anhydrous magnesium sulfate,The organic phase was evaporated to give a crude product,The crude product was recrystallized to give 6.52 g of the compound of formula IV-1,The yield was 80percent.
The synthetic route of 1455-77-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fuyang Xinyihua Material Technology Co., Ltd; Wu, Jingwei; (17 pag.)CN105294664; (2016); A;,
1,2,3-Triazole – Wikipedia,
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