1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H7N3O2
A solution of (3S,6R)-6-methylpiperidin-3-ol (2.36 g, 20.5 mmol), 2-(2H- 1,2,3- triazol-2-yl)benzoic acid (4.65 g, 24.6 mmol), EDC (7.86 g, 41.0 mmol), l-hydroxy-7- azabenzotriazole (5.58 g, 41.0 mmol), and triethylamine (8.57 mL, 61.5 mmol) in DMF (130 mL) was stirred at 50 C overnight, then diluted with saturated aqueous sodium bicarbonate and extracted 5x with ethyl acetate. The organics were washed with brine, dried over magnesium sulfate, filtered, and concentrated. The crude material was purified by silica gel gradient chromatography (0-100% ethyl acetate in hexanes), providing the titled compound as a peach- colored solid. LRMS m/z (Mu+Eta) 287.4 found, 287.1 required.
The synthetic route of 1001401-62-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SKUDLAREK, Jason, W.; WO2015/95108; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics