Synthetic Route of 23579-79-5, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 23579-79-5, name is 3,5-Dibromo-1-methyl-1H-1,2,4-triazole, molecular formula is C3H3Br2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
In a 25 mL pressure vial, 3,5-dibromo-1-methyl- 1H-1,2,4-triazole (lnt-41, 424 mg, 1.76 mmol) was dissolved in DMF (5 mL) and potassium carbonate (375 mg, 2.71 mmol), followed by 3- chlorophenol (176 mg, 141 L, 1.36 mmol) were added. The vial was sealed, the reaction mixture was stirred for 15 h at 100 C. After cooling, it was concentrated in vacuo, the residue was purified by column chromatography (silica gel, 70 g, eluting with ethyl acetate / n-heptane, gradient 0: 100 to 30:70 v/v) to yield the title compound as white solid (388 mg, 99%). 1H NMR (CDCl3, 300 MHz): delta 3.78 (s, 3 H), 7.21-7.28 (m, 2 H), 7.32-7.39 (m, 2 H). MS (ES+) m/z 288.0, 290.0, 292.0 [M+H, Br & CI isotopes] .
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 3,5-Dibromo-1-methyl-1H-1,2,4-triazole, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; BERCHTOLD, Stefan; GALLEY, Guido; GOERGLER, Annick; JAKOB-ROETNE, Roland; KRUMMENACHER, Daniela; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; RODRIGUEZ SARMIENTO, Rosa Maria; SCHNIDER, Christian; (309 pag.)WO2018/87018; (2018); A1;,
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