Synthetic Route of 288-36-8, The chemical industry reduces the impact on the environment during synthesis 288-36-8, name is 1H-1,2,3-Triazole, I believe this compound will play a more active role in future production and life.
To a mixture of 2-bromo-4-fluorobenzoic acid (30 g, 137 mmol) , cesium carbonate (89.26 g, 274 mmol) , and CuI (5.27 g, 27.4 mmol) in DMF (200 mL) was added N, N? -dimethylcyclohexane-1, 2-diamine (3.7 mL, 23.3 mmol) and 1H-1, 2, 3-triazole (18.92 g, 274 mmol) . The resulting mixture was stirred at 110 overnight, cooled, concentrated in vacuo, and diluted with water (150 mL) . The aqueous layer was washed with EtOAc (300 mL x 3) . The aqueous layer was acidified with 2 N HCl and extracted with EtOAc (300 mL x 4) . The combined organic layers were washed with brine (150 mL x 3) , dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography (petroleum ether: EtOAc100: 15: 1) to provide the title compound as a solid. LRMS m/z (M+H) 208.0 found, 208.0 required.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,3-Triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; (59 pag.)WO2016/101118; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics