Research on new synthetic routes about 288-88-0

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-88-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-88-0, name is 1H-1,2,4-Triazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C2H3N3

Catalyst 1: sodium 1,2,4-triazolate 200 ml of dry methanol and 48 ml of a 30% solution of sodium methanolate in methanol, corresponding to 0.25 mol sodium methanolate, were put first into a three-necked flask agitator with a mechanical stirrer, internal thermometer and reflux cooler, with dry nitrogen. 17.4 g (0.25 mol) of 1,2,4-triazole was added in portions at room temperature. When the addition of the 1,2,4-triazole had been completed the reaction mixture was agitated for 4 hours at reflux temperature. The solvent was then distilled off at reduced pressure and the oily residue left was mixed with 200 ml of methylene chloride at room temperature. The mixture was agitated for 15 minutes at room temperature and the product precipitated as a solid was filtered off. 22.5 g sodium-1,2,4-triazolate (yield 98%) was obtained in the form of a colorless powder.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-88-0.

Reference:
Patent; Laas, Hans-Josef; Halpaap, Reinhard; Richter, Frank; Kocher, Jurgen; US2003/13872; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics