Reference of 7170-01-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
Example 48 b. 3-methyl-l-(4-nitrophenyl)-lH-l,2,4-triazole3-methyl-lH-l,2,4-triazole (648 mg, 7.8 mmol) and potassium carbonate (2.0 g, 14.2 mmol) were added to a solution of l-fluoro-4-nitro-benzene (1.0 g, 7.1 mmol) in DMF (10 mL). The reaction mixture was heated in a sealed tube at 800C overnight, cooled to room temperature and filtered through a pad of Celite. The solids were washed with dichloromethane and the filtrate was concentrated under reduced pressure. The residue was taken in water and the resultant precipitate was collected by filtration, washed with water and dried under high vacuum to afford 950 mg of the title compound (67 % Yield). 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 2.51 (s, 3 H) 7.83 -7.89 (m, 2 H) 8.36 – 8.41 (m, 2 H) 8.58 (s, 1 H). MS m/z: 205 [M+l]+ .
The synthetic route of 3-Methyl-1H-1,2,4-triazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; LO-ALFREDSSON, Yvonne; PAULSEN, Kim; RAKOS, Laszlo; ROTTICCI, Didier; WALDMAN, Magnus; WO2010/132015; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics