Related Products of 1001401-62-2, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, molecular formula is C9H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Example 22 2-(2H-1,2,3-Triazol-2-yl)-N-(2-{[4-(trifluoromethyl)pyridin-2-yl]methyl}cyclopentyl)benzamide Triethylamine (0.099 ml, 0.71 mmol), 3H-[1,2,3]triazolo[4,5-b]pyridin-3-ol (0.039 g, 0.29 mmol) and EDC (0.055 g, 0.29 mmol) were added to a solution 2-{[4-(trifluoromethyl)pyridin-2-yl]methyl}cyclopentan-1-amine (Intermediate 12; 0.058 g, 0.24 mmol) and 2-(2H-1,2,3-triazol-2-yl)benzoic acid (CAS number 1001401-62-2; 0.054 g, 0.29 mmol) in DCM (3 ml). The reaction was stirred at room temperature for 24 hours and then diluted with DCM (40 ml) and washed with a saturated solution of sodium bicarbonate (10 ml). The organics were dried over magnesium sulfate, filtered through a hydrophobic frit and concentrated in vacuo. The crude product was purified by column chromatography (silica, 0-80% ethyl acetate/petrol) to afford the title compound. 1H NMR (400 MHz, DCM-d2) delta ppm 1.19-1.31 (m, 1H), 1.39-1.49 (m, 1H), 1.50-1.64 (m, 2H), 1.65-1.75 (m, 1H), 1.91-2.02 (m, 1H), 2.48-2.59 (m, 1H), 2.68-2.76 (m, 1H), 3.00-3.08 (m, 1H), 4.36-4.45 (m, 1H), 6.45-6.53 (m, 1H), 7.30-7.34 (m, 1H), 7.37 (s, 1H), 7.48-7.54 (m, 1H), 7.55-7.61 (m, 1H), 7.62-7.66 (m, 1H), 7.71-7.75 (m, 1H), 7.82 (s, 2H) and 8.59-8.62 (m, 1H). MS ES+: 416 Example 23 2-(2H-1,2,3-Triazol-2-yl)-N-(2-{[4-(trifluoromethyl)pyridin-2-yl]methyl}cyclopentyl)benzamide Prepared according to the procedure for 2-(2H-1,2,3-triazol-2-yl)-N-(2-{[4-(trifluoromethyl)pyridin-2-yl]methyl}cyclopentyl)benzamide (Example 22) except this was then was chirally separated using SFC (Waters prep30/MS system using 20% Ethanol, Daicel IA 10 mm id×250 mm long columns at 30 ml min, 40 C. and 100 bar) to afford the title compound as a single enantiomer. 1H NMR (300 MHz, DCM-d2) delta ppm 1.15-1.35 (m, 1H), 1.35-1.79 (m, 4H), 1.85-2.06 (m, 1H), 2.42-2.63 (m, 1H), 2.64-2.79 (m, 1H), 2.95-3.16 (m, 1H), 4.28-4.53 (m, 1H), 6.44-6.59 (m, 1H), 7.26-7.43 (m, 2H), 7.43-7.68 (m, 3H), 7.69-7.77 (m, 1H), 7.82 (s, 2H), 8.54-8.68 (m, 1H). MS ES+: 416
We very much hope you enjoy reading the articles and that you will join us to present your own research about 1001401-62-2, Happy reading!
Reference:
Patent; Takeda Pharmaceutical Company Limited; Fieldhouse, Charlotte; Glen, Angela; Maine, Stephanie; Fujimoto, Tatsuhiko; Robinson, John Stephen; US2015/232460; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics