Synthetic Route of 1001401-62-2, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 2-(2H-l,2,3-triazol-2-yl)benzoic acid (500 mg, 2.64 mmol) in SOCI2 (5 mL) was heated to reflux for 1 hour. After cooling to RT, the mixture was concentrated in vacuo to give a residue. To a solution of ((3R,6R)-6-methylpiperidin-3- yl)methanol hydrochloride (437 mg, 2.65 mmol) in toluene (5 mL) was added 1 N NaOH (5.3 mL), followed by a solution of the reaction residue in toluene (5 mL) dropwise. The resulting mixture was stirred at 10C for 12 h, then poured into water (5 mL) and extracted with EtOAc (5 mL x 3). The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (20-50 % EtOAc in petroleum ether) to afford the title compound as a solid. LRMS m/z (M+H) 301.1 found, 301.2 required.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 1001401-62-2.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott, D.; LUO, Yunfu; MENG, Na; YU, Tingting; (83 pag.)WO2016/69510; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics