New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.1455-77-2, name is 3,5-Diamino-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 1455-77-2
2-Hydroxybenzaldehyde (0.02 mol L1, 2 mL) in ethanol (10 mL)was added to a magnetically stirred solution of 3,5-diamino-1,2,4-triazole (0.01 mol L1, 0.99 mg) in ethanol (20 mL). The mixture was refluxed for 2 h. The reaction was monitored through TLC.During refluxing yellow precipitates started forming. It was refluxed for another half an hour. It was then cooled to room temperature, filtered, washed with cold ethanol (2 10 mL) thenwith ether (2 5 mL), dried and recrystallized in a mixture of hot ethanol and ether (2:1).2.3. 2-{(E)-[(3-{[(Z)-(2-hydroxyphenyl)methylidene]amino}-1H-1,2,4-triazol-5-yl)imino]methyl}phenol (L)Yield: (1.63 g, 75percent); mp: 244 °C; color (yellow): IR (cm-1): 3429(OH), 3195 (N-H), 1634 (HC=N), 1604 (C=N) and 1023 (N-N); 1HNMR (ppm DMSO?d6): d 12.81 (s, 1H, NH), 12.14 (s, 1H, OH), 9.16 (s,2H, C7-H, C7,-H), 6.97-7.69 (m, Ar-H); 13C NMR (DMSO?d6):d 157.19 (C8,C8,), 160.67 (C7,C7,), 168.54 (C1, C1,), 117.05-133.93(Ar-C); Mass Spectrum EIMS m/z (percent): 307.31: [M], 308.0(10),277.1(17), 204.1(13), 185.1(100), 171.1(6), 157.0(4). Anal. Calc. for C16H13N5O2 (307.31): C, 62.53 (62.45); H, 4.26 (4.20); N, 22.79(22.72).
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 3,5-Diamino-1,2,4-triazole ,and how the biochemistry of the body works.
Reference:
Article; Sumrra, Sajjad Hussain; Kausar, Samia; Raza, Muhammad Asam; Zubair, Muhammad; Zafar, Muhammad Nadeem; Nadeem, Muhammad Arif; Mughal, Ehsan Ullah; Chohan, Zahid Hussain; Mushtaq, Fazila; Rashid, Umer; Journal of Molecular Structure; vol. 1168; (2018); p. 202 – 211;,
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