Reference of 16681-70-2, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
[0427] To a stirred solution of (2S,4S)-4-amino-5-bipheny1-4-y 1-2-(3 -hydroxypropoxymethy l)pentanoic acid ethy Iester (18 mg, 47 flillOI) in DMF (0.3 mL), was added IH-1,2,3-triazole-4-carboxylic acid (5.3 mg, 47 f.tmol) and HATU (18mg, 47 f.tmol), followed by DIPEA(25 f.LL, 141 f.tmol). Themixture was stirred for 30 minutes, then concentrated underreduced pressure to yield crude Compound I, which was usedin the next step without purification.
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Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics