Sandahl, Alexander F.; Nguyen, Thuy J. D.; Hansen, Rikke A.; Johansen, Martin B.; Skrydstrup, Troels; Gothelf, Kurt V. published an article in 2021. The article was titled 《On-demand synthesis of phosphoramidites》, and you may find the article in Nature Communications.Product Details of 288-36-8 The information in the text is summarized as follows:
Automated chem. synthesis of oligonucleotides is of fundamental importance for the production of primers for the polymerase chain reaction (PCR), for oligonucleotide-based drugs, and for numerous other medical and biotechnol. applications. The highly optimized automised chem. oligonucleotide synthesis relies upon phosphoramidites as the phosphate precursors and one of the drawbacks of this technol. is the poor bench stability of phosphoramidites. Here, we report on the development of an on-demand flow synthesis of phosphoramidites from their corresponding alcs., which is accomplished with short reaction times, near-quant. yields and without the need of purification before being submitted directly to automated oligonucleotide synthesis. Sterically hindered as well as redox unstable phosphoramidites are synthesized using this methodol. and the subsequent couplings are near-quant. for all substrates. The vision for this technol. is direct integration into DNA synthesizers thereby omitting manual synthesis and storage of phosphoramidites. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Product Details of 288-36-8)
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Product Details of 288-36-8
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics