On September 30, 2022, Sandeep, K.; Sanjeeva Kumar, A.; Qureshi, Asif Ali; Kumara Swamy, K. C. published an article.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was (3+2) Cycloadditions of Vinyl Sulfonyl Fluorides with Ethyl Diazoacetate or Azides: Metal-Free Synthesis of Pyrazole and Triazole Scaffolds via SO2 Elimination. And the article contained the following:
A (3 +2) cycloaddition reaction between substituted vinyl sulfonyl fluorides RCH=CHS(O)2F (R = Ph, 2,4,6-trimethylphenyl, naphthalen-2-yl, etc.) and 3,4-dihydronaphthalene-2-sulfonyl fluoride and Et diazoacetate or azides R1N3 (R1 = Ph, Bn, 4-nitrophenyl, etc.) for the rapid construction of pyrazole I or triazole cores II (R1 = H, Ph, Bn, 4-nitrophenyl, etc.) via Michael addition and SO2 gas elimination is developed. Trimethylsilyl azide or organic azide selectively attacks at the β-carbon of vinyl sulfonyl fluoride rather than at the S(VI) center and generates C-substituted or C,N-disubstituted triazole II. In contrast, vinyl sulfonyl fluorides react with Et diazoacetate to generate pyrazoles I in good to high yields. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole
The Article related to pyrazole preparation chemoselective, ethyl diazoacetate vinyl sulfonyl fluoride cycloaddition michael addition, triazole preparation chemoselective, azide vinyl sulfonyl fluoride cycloaddition michael addition and other aspects.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics