Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Lahmidi, S; Anouar, EH; El Hafi, M; Boulhaoua, M; Ejjoummany, A; El Jemli, M; Essassi, EM; Mague, JT in [Lahmidi, Sanae; El Hafi, Mohamed; Boulhaoua, Mohammed; Essassi, El Mokhtar] Mohammed V Univ Rabat, Ctr Rech Sci Med, Pole Competences Pharmacochim, Lab Chim Organ Heterocycl,Fac Sci,URAC 21, Ave Ibn Battouta,BP 1014, Rabat, Morocco; [Anouar, El Hassane] Prince Sattam Bin Abdulaziz Univ, Coll Sci & Humanities, Dept Chem, BP 830, Al Kharj, Saudi Arabia; [Ejjoummany, Abdelaziz] Univ Hassan II Casablanca, EST Mohammedia, Lab Chim Phys & Chim Bioorgan, BP 146, Mohammadia 28800, Morocco; [El Jemli, Meryem] Mohammed V Univ, Fac Med & Pharm, Lab Pharmacol & Toxicol, Pharmacodynamy Res Team,ERP,Rabat Inst, BP 6203, Rabat, Morocco; [Mague, Joel T.] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA published Synthesis, X-ray, spectroscopic characterization, DFT and antioxidant activity of 1,2,4-triazolo[1,5-a]pyrimidine derivatives in 2019.0, Cited 60.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.
Two new (4-5) and a known (3) derivatives of 1,2,4-triazolo [1,5-a]pyrimidine are synthesized and characterized through spectroscopic NMR, FT-IR and single crystal X-ray diffraction techniques. Along with experimental data, the predicted spectral data are obtained using density functional theory (DFT) at the B3LYP/6-31 + G (d,p) level of theory. The closest contacts between active atoms of the compounds are identified through Hirshfeld surface analysis and electrostatic potential map (EPM) studies. Relatively, good correlations were found between the experimental and predicted spectroscopic data with correlation coefficients higher than 90%. Hirshfeld surface analysis and EPM reveal that the closest interaction between the units of the compounds are between hydrogen atoms (39.6-46.3%). The antioxidant activity of 3-5 is evaluated using DPPH free radical scavenging and ferric reducing antioxidant power assays. (C) 2018 Elsevier B.V. All rights reserved.
Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lahmidi, S; Anouar, EH; El Hafi, M; Boulhaoua, M; Ejjoummany, A; El Jemli, M; Essassi, EM; Mague, JT or concate me.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
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