Reference of 7170-01-6, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
200 mg of intermediate 35, 60% sodium hydride(Oil) 30 mg, and DMF 2 mL,47 mg of 3-methyl-1H-1,2,4-triazole was added under ice cooling. After stirring for 2.5 hours under ice cooling,Saturated multilayer aqueous solution was added to the reaction mixture,And extracted with ethyl acetate. The organic layer was washed with water,And saturated brine, and dried over anhydrous sodium sulfate. The obtained organic layer was dried under reduced pressure.The obtained residue was subjected to silica gel chromatography,120 mg of Compound 247 of the present invention described below was obtained.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 3-Methyl-1H-1,2,4-triazole, hurry up and to see.
Reference:
Patent; Sumitomo Chemical; Ikari, Kaori; (123 pag.)JP2019/6686; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics