New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Product Details of 16681-70-2
[0635] Compound 1 (500 mg, 1.4 mmol) was combinedwith HATU (656 mg, 1.7 mmol), 3H-[1,2,3]triazole-4-carboxylicacid (195 mg, 1.7 mmol) and DMF (3 mL). DIPEA(803 f.LL, 4.6 mmol) was added and the mixture was stirred for30 minutes. Saturated aqueous NH4Cl (10 mL) and EtOAc(40 mL) were added. The organic layer was separated anddried over MgS04 . The solvent was evaporated and the residuepurified by normal phase chromatography (0-1 00%EtOAc/hexanes) to yield Compound 2 (650 mg).
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1H-[1,2,3]Triazole-4-carboxylic acid ,and how the biochemistry of the body works.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics