Diazo aldehyde chemistry. Part 3. synthesis of 4-acyl-1H-1,2,3-triazole derivatives was written by Sezer, Oezkan;Dabak, Kadir;Akar, Ahmet;Anac, Olcay. And the article was included in Helvetica Chimica Acta in 1996.Computed Properties of C5H7N3O2 This article mentions the following:
Ten α-diazo-β-oxo aldehydes were condensed with PhNH2, NH3, NH2OH, and NH2CONHNH2 to yield 1-substituted 4-acyl-1H-1,2,3-triazoles in moderate to good yields. The method is simple and regiospecific. Thus, it is superior to the widely used acylacetylene and azide approach. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Computed Properties of C5H7N3O2).
Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Computed Properties of C5H7N3O2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics