6523-49-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6523-49-5 name is 4-(1,2,4-Triazol-1-yl)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of the formamidine from step 1 (304 mg) and 4-triazolylaniline (75 mg) in AcOH (2 ml) was heated to 125 for 1.5 h. After cooling, the mixture was diluted and basified with IN NaOH (20 ml). The resulting ppt was isolated by filtration and dried to give the title compound (136 mg, 71 %) as a yellow solid.1H NMR delta 10.07 (IH3 s), 9.28 (IH, s), 8.78 (IH, s), 8.62 (lH,s), 8.25 (IH, s), 8.16 (IH, d, J 8.85Hz), 8.07 (2H, d, J 8.85Hz), 7.86 (2H, d, J 8.85Hz), 7.82 (IH, d, J 8.85Hz), 7.47 (IH, d, J 1.9Hz), 7.38 (IH, dd, J 8.2, 1.9Hz), 7.03 (IH, d, J 8.85Hz) 4.32 (4H, s); LC-MS rt 2.35 m/z 423 ES+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(1,2,4-Triazol-1-yl)aniline, and friends who are interested can also refer to it.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics