7170-01-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
[0907] A suspension of 6-bromo-7 -( dimethoxymethyl)-1,2,3,4-tetrahydro-1 ,8-naphthyridine (intermediate 12) (300mg, 1.045 mmol), 3-methyl-lH-1,2,4-triazole (104 mg,1.254 mmol), Cs2C03 (720 mg, 2.210 mmol) and Cui ( 40 mg,0.210 mmol) in DMF (2 ml) was heated to 120 C. forapproximately 6 h. The reaction mixture was diluted withethyl acetate and water, layers were separated and the aqueouslayer was extracted with ethyl acetate (3x). Organic layerswere combined, washed with water and brine, dried usingNa2S04 , filtered, evaporated. The crude product was purifiedby silica gel colunm chromatography eluting with a gradientof MeOH (1-10%) in DCM. Product fractions were combined,evaporated and dried to yield the title compound as anorange resin. (UPLC-MS 3) tR 0.57 min; ESI-MS 290.1[M+H]+. 1HNMR(400MHz, CDCI3 ) o8.21 (s, lH), 7.21 (s,lH), 5.35 (s, lH), 4.95 (s, lH), 3.51-3.41 (m, 2H), 3.36 (s,6H), 2.75 (t, 2H), 2.47 (s, 3H), 1.97-1.86 (m, 2H).
The synthetic route of 3-Methyl-1H-1,2,4-triazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Novartis AG; Buschmann, Nicole; Fairhurst, Robin Alec; Furet, Pascal; Knoepfel, Thomas; Leblanc, Catherine; Liao, Lv; Mah, Robert; Nimsgern, Pierre; Ripoche, Sebastien; Xiong, Jing; Han, Bo; Wang, Can; Zhao, Xianglin; US2015/119385; (2015); A1;,
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