These common heterocyclic compound, 930-33-6, name is 1H-1,2,4-Triazol-3(2H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 930-33-6
509 g (28.28 mol) of water are added to a solution of the obtained OTA (in 98% sulfuric acid) with stirring and then 213 g (3.38 mol) of concentrated nitric acid (98% by weight commercial nitric acid) are added.After the introduction of nitric acid, the medium was brought to 65 DEG C and stirred at this temperature for 2 hoursSamples are taken to monitor the progress of the nitration (when the temperature of the reaction medium reaches 65 ). The sample is analyzed after external calibration (using commercial ONTA). The results are shown in Fig. Can be obtained at a very high yield.The following procedure was carried out for the recovery of the prepared ONTA.The reaction medium is cooled to 10 C (at the expiry of 2 hours). Subsequently, an amount of 293 g (16.28 mol) of water is added while maintaining the temperature at 10 . The crystallized ONTA is then filtered off and then pull-dried on a Buchner filter.The weight of the recovered wetted ONTA is 403 g.HPLC analysis (of the recovered ONTA) shows that after external calibration (by commercial ONTA), a yield of 96% of the wet product (for the starting ATA) can be achieved.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 930-33-6.
Reference:
Patent; Hercules; Yurenko; Herve, Gregoire; Jacob, Gi; Kanyong, Gi; Busay, Jang Marque; (13 pag.)KR2016/28405; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics