Reference of 956317-36-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 956317-36-5 as follows.
A round-bottom flask equipped with a magnetic stirrer bar was charged with CH2C12(70 mL) and 5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoic acid (2.Og, 9.4 mmol, 1 equiv).To the clear solution, pentafluoro phenol (1.72 g, 9.4 mmol, 1 equiv) and EDChydrochloride (1.79 g, 9.4 mmol, 1 equiv) were successively added. After addition ofDMAP (0.23 g, 1.9 mmol, 0.2 equiv), the clear solution was stirred at room temperature for 2 h. The reaction mixture was evaporated to dryness under reduced pressure and purified by column chromatography (Si02, cyclohexane/ethyl acetate 9: 1), yielding perfluorophenyl 5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoate (2.5 g, 72 %) as a colorlesspowder.?H NMR (500 MHz, CDC13) oe = 7.83 (s, 2H), 7.78 (d, J = 8.20 Hz, 1H), 7.76 (d, J = 1.40, 1H), 7.54 (dd, J = 1.40, 8.25 Hz, 1H), 2.51 (s, 3H)?3C NMR (125 MHz, CDC13) oe = 162.8, 139.2, 136.6, 136.1, 134.0, 131.1, 124.6, 123.6, 21.1 (CM omitted due to low intensity)?9F NMR (470 MHz, CDC13) oe = -151.2 (m), -157.8 (t, J = 21.7 Hz), -162.3 (m)
According to the analysis of related databases, 956317-36-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANDOZ AG; HOeFERL-PRANTZ, Kathrin; BARTH, Roland; RICHTER, Frank; ZUPANCIC, Borut; (126 pag.)WO2016/20403; (2016); A1;,
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