41253-21-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, A new synthetic method of this compound is introduced below.
To a solution of phenol 11a (200 mg, 0.441 mmol) and cesium carbonate (158 mg, 0.485 mmol) in DMF (10 mL) was added 1,2-dibromoethane (96 muL, 1.11 mmol). The resulting mixture was stirred at room temperature for 60 h. After dilution with water, the mixture was extracted with EtOAc. The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo. The residue was carried on to the next step without further purification.To a solution of the crude bromide in DMF (10 mL) was added 1,2,4-triazole sodium derivative (122 mg, 1.34 mmol). The mixture was stirred at room temperature for 15 h. After dilution with water, the mixture was extracted with EtOAc. The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo. The residue was purified using RP preparative HPLC to provide the titled compound 11g (78 mg, 33%, 2 steps). 1H NMR (400 MHz, DMSO-d6) delta 8.59 (s, 1H), 8.02 (s, 1H), 7.95 (s, 1H), 7.77-7.71 (m, 1H), 7.47 (s, 1H), 7.13 (s, 1H), 6.78 (d, J = 3.2 Hz, 1H), 6.62-6.58 (m, 1H), 5.02-4.92 (m, 2H), 4.71-4.35 (m, 8H), 3.71-3.61 (m, 1H), 3.49-3.41 (m, 1H), 3.38-3.15 (m, 5H); MH+ 549.
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Reference:
Article; Lee, Suk Ho; Kim, Min Ju; Lee, Sung-Han; Kim, Jeongmin; Park, Hyun-Ju; Lee, Jinhwa; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 2662 – 2675;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics