Sharma, Pankaj; Kumar, Niggula P.; Senwar, Kishna R.; Forero-Doria, Oscar; Nachtigall, Fabiane M.; Santos, Leonardo S.; Shankaraiah, Nagula published an article in 2017, the title of the article was Effect of sulfamic acid on 1,3-dipolar cycloaddition reaction: mechanistic studies and synthesis of 4-aryl-NH-1,2,3-triazoles from nitroolefins.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:
A facile and new metal-free 1,3-dipolar cycloaddition reaction for the synthesis of 4-aryl-NH-1,2,3-triazoles, e.g., I from nitroolefins, e.g., 3-nitro-2-phenyl-2H-1-benzopyran and NaN3 employing NH2SO3H has been developed. Sulfamic acid proved to be an efficient additive in this transformation by inhibiting the formation of triaryl benzene. Mechanistic aspects and key intermediates associated with this transformation have also been characterized by online monitoring of the reaction using electrospray ionization tandem mass spectrometry method (ESI-MS/MS). The protocol emphasizes broad substrate scope for many functionalities, simple reaction conditions such as stability to open air, less reaction time, easy work-up, eco-friendly and with good to excellent yields. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Safety of 4-(p-Tolyl)-1H-1,2,3-triazole
The Article related to triazole aryl preparation green chem, nitroolefn sodium azide dipolar cycloaddition reaction sulfamic acid catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics