Shchepin, Roman published the artcileInfluence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans, Recommanded Product: Sodium 1,2,3-triazole-5-thiolate, the publication is Bioorganic & Medicinal Chemistry (2008), 16(4), 1842-1848, database is CAplus and MEDLINE.
A series of synthetic mols. combining a geranyl backbone with a heterocyclic or oxime head group are quorum-sensing mols. that block the yeast to mycelium transition in the dimorphic fungus Candida albicans. A number of the analogs have an IC50 ≤ 10 μM, a level of potency essentially identical to the natural quorum sensing signal, the sesquiterpene farnesol. Two of the most potent analogs, neither toxic toward healthy mice, display remarkably different effects when co-administered with C. albicans. While neither offers protection from candidiasis, one analog mimics farnesol in acting as a virulence factor, whereas the other has no effect. The results offer the first example of highly potent synthetic fungal quorum-sensing mols., and provide the first evidence for the ability to decouple quorum sensing and virulence.
Bioorganic & Medicinal Chemistry published new progress about 59032-27-8. 59032-27-8 belongs to triazoles, auxiliary class Triazoles, name is Sodium 1,2,3-triazole-5-thiolate, and the molecular formula is C13H16BFO3, Recommanded Product: Sodium 1,2,3-triazole-5-thiolate.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics