Sheng, Chunquan published the artcileSynthesis and antifungal activity of 1-(1,2,4-triazolyl-1H-1-yl)-2-(2,4-diflurophenyl)-3-(4-substituted benzyl-1-piperazinyl)-2-propanols, Formula: C12H13F2N3O4S, the publication is Yaoxue Xuebao (2003), 38(9), 665-670, database is CAplus and MEDLINE.
A series of triazole antifungals were synthesized to search for novel triazole antifungals with more potent activity, less toxicity, and broader spectrum. Nineteen new 1-(1H-1,2,4-triazolyl-1-yl)-2-(2,4-diflurophenyl)-3-[4-(4-R-benzyl)-1-piperazinyl]-2-propanols I (R = p-t-Bu, halo, Me, nitro, Et, and/or cyano) were designed and synthesized based on the three dimensional structure of P 450 cytochrome 14α-sterol demethylase (CYP51), and their antifungal activities were also evaluated. The preliminary biol. tests showed that most of the title compounds exhibited high activity against eight common pathogenic fungi and the activities against deep fungi were higher than those against shallow fungi. Most of the title compounds showed higher antifungal activities than Fluconazole and Terbinafine.
Yaoxue Xuebao published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H16N2O2, Formula: C12H13F2N3O4S.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics