Sheng, Chunquan published the artcileSynthesis and antifungal activity of novel triazole antifungal agents, Category: triazoles, the publication is Yaoxue Xuebao (2004), 39(12), 984-989, database is CAplus and MEDLINE.
21 1-(1H-1,2,4-triazolyl)-2-(2,4-difluorophenyl)-3-(4-substituted-1-piperazinyl)-2-propanol derivatives were synthesized based on the three-dimensional structure of P 450 cytochrome 14α-sterol demethylase (CYP51), and their antifungal activities were also evaluated. Results of preliminary biol. tests showed that most of the synthetic compounds exhibited activities against the eight common pathogenic fungi to some extent and the activities against deep fungi were higher than those against shallow fungi. In general, Ph and pyridinyl analogs showed higher antifungal activity than the phenylacyl analogs. Several synthetic compounds showed higher antifungal activities than fluconazole and terbinafine. Four of them, e.g. I, showed the best antifungal activities with broad antifungal spectrum and were chosen for further study.
Yaoxue Xuebao published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C6H6N2O, Category: triazoles.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics