Sheng, Chunquan published the artcileSynthesis of N-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-N’-phenyl-1,2,4-triazol-3-one derivatives as fungicides, Product Details of C12H13F2N3O4S, the publication is Zhongguo Yaoxue Zazhi (Beijing, China) (2006), 41(6), 469-471, database is CAplus.
A series of triazole antifungal agents were synthesized in order to discover highly active, low-toxicity, broad-spectrum compounds 2-[2-(2,4-Difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(phenyl)-1,2,4-triazol-3-one derivatives were designed and synthesized on the basis of the three dimensional structure of P 450 cytochrome-dependent 14α-sterol demethylase (CYP51). Their antifungal activities were also evaluated. The results of preliminary biol. tests showed that all compounds exhibited activity against eight common pathogenic fungi, and the activities against deep fungi were higher than that against shallow fungi. The compounds thus prepared were screened against Cryptococcus neoformans, Candida albicans, Candida tropicalis, Candida parapsilosis, Fonsecaea pedrosoi, Trichophyton rubrum, Sporothrix schenckii. All the title compounds showed high antifungal activities against Candida albicans. One compound showed optimum antifungal activity with broad antifungal spectrum, and is chosen for further structural optimization.
Zhongguo Yaoxue Zazhi (Beijing, China) published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C18H10, Product Details of C12H13F2N3O4S.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics