In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 129027-65-2, name is 1-(tert-Butyl)-1H-1,2,3-triazole-4-carbaldehyde belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Safety of 1-(tert-Butyl)-1H-1,2,3-triazole-4-carbaldehyde
Synthesis of N,N-bis((1-tert-butyl-1H-1,2,3-triazol-4-yl)methyl)prop-2-yn-1-amine To a 250-mL round bottom flask was added a solution of 1-tert-butyl-1H-1,2,3-triazole-4-carbaldehyde (2.47 g, 16.1 mmol, 2.2 eq) in 84 mL dichloroethane (?0.2 M), followed by addition of propargyl amine (361 mg, 7.2 mmol, 1.0 eq). To this mixture sodium triacetoxyborohydride (3.8 g, 17.9 mmol, 2.5 eq) was added in one portion with vigorous stirring. The reaction mixture was stirred at rt for 40 h. 1N H2SO4 (86 mL) was added to the reaction, and the mixture was stirred for 15 min. The pH was adjusted to >10 by addition of potassium carbonate. The reaction mixture was diluted with 100 mL of water and extracted with dichloromethane (3*300 mL). The organic layers were combined, dried over anhydrous MgSO4, filtered, and concd in vacuo to provide a crude product.Further purification by flash chromatography (100 g silica gel, 20% hexanes in EtOAc, Rf 0.2, KMnO4 stain) provided 1.98 g of product (yield: 84%) as a white powder. mp 125.5-126.1 C.; 1H NMR (300 MHz, CDCl3) delta 7.67 (s, 2H), 3.87 (s, 4H), 3.40 (d, J=2.4 Hz, 2H), 2.28 (t, J=2.4 Hz, 1H), 1.67 (s, 18H); 13C NMR (75 MHz, CDCl3) delta 143.6, 120.2, 78.8, 73.5, 59.2, 47.8, 42.2, 30.0; HRMS cacld for [M+H]+ C17H28N7 330.2406, found 330.2400.
The synthetic route of 129027-65-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Albert Einstein College of Medicine of Yeshiva Uni; Wu, Peng; Soriano del Amo, David; Wang, Wei; Marlow, Florence L.; US2013/295019; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics