Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4928-87-4, name is 1,2,4-Triazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., 4928-87-4
The intermediate 27a was added(0.2 g, 0.39 mmol) was dissolved in 35 ml of DMF, EDCI (0.08 g, 0.42 mmol) was added,HOBT, (0.058, 0.38 mmol) was dissolved with stirring, and then ml, 2,4-triazole-3-carboxylic acid (0.058,0.44mmo 1), DIEA 0.2ml (1.17mmo 1), stirring at room temperature for 12h, TLC detection, the end of the reaction, the liquid spin dry crude, crudeThe product was purified by silica gel G column chromatography [eluent (methanol: dichloromethane) = 50: 500 (nu: nu)] to give the title compound0 ¡¤ 08g, yield 33.3%
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Reference:
Patent; Beijing Foreland Pharma Co., Ltd; Zhang, Xingmin; Wang, Ensi; Niu, Shengxiu; Guo, Jing; Dai, Zhuolin; Zheng, Nan; Ji, Qi; Li, Qinyan; Liang, Tie; (109 pag.)CN104411706; (2016); B;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics