These common heterocyclic compound, 1533519-84-4, name is 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Compound 10 was synthesized with reference to Patent CN10352440A reported. Compound 10 (50. 00mg,187 ¡¤ 02umol, 1 ¡¤ OOeq), compound 14 (54. 56mg, 224. 42umol, 1 ¡¤ 20eq) and potassium carbonate (31. 02mg,224. 42umol, 1.20eq) were dissolved in N, Nu- dimethylformamide (10. OOmL), and the reaction was stirred between 15 C under 2.5 hours. After completion of the reaction, the reaction solution was spin-dried to give the crude product as a yellow solid. The crude product is purified by PTLC thin layer chromatography (developingSolvent: 50% ethyl acetate / petroleum ether) to give compound 15 as a colorless oil.
The synthetic route of 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Matilda drug R & D Co., Ltd.; Wang, Jainfei; Zhang, Jing; Zhang, Long; Zhang, Yang; Li, Jian; Chen, Shuhui; (43 pag.)CN105622531; (2016); A;,
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