Related Products of 16681-70-2,Some common heterocyclic compound, 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0625] (2S,4S)-4-Amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-cyanomethylpentanoic acid ethyl ester (55 mg, 141f.tmol) was combined with 3H-[1,2,3]triazole-4-carboxylicacid (19.2 mg, 170 f.tmol), HATU (64.5 mg, 170 flillOI) andDIPEA (79 f.LL, 453 f.tmol) in DMF (2 mL) and was stirred atroom temperature for 30 minutes then concentrated in vacuo and the crude residue was purified by normal phase chromatography(0-100% EtOAc/hexanes) to yield Compound 1.55mg).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-[1,2,3]Triazole-4-carboxylic acid, its application will become more common.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics