Simple exploration of 288-36-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,3-Triazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 288-36-8, name is 1H-1,2,3-Triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-36-8, Formula: C2H3N3

To a solution of lH-l,2,3-triazole (5.0 g, 72.3 mmol) and K2CO3 (9.1 g, 65.8 mmol) in acetone at 560C was added benzyl bromide (7.8 ml, 65.8 mmol) drop wise over 90 minutes. The reaction mixture was heated at reflux for a further Ih, cooled to room temperature and quenched with distilled water (4 ml). Acetone was evaporated in vacuo and the remaining aqueous phase back extracted with DCM (3 x 20 ml). The combined organic layers were dried (MgStheta4), filtered and concentrated in vacuo to provide the title compound (9.8 g, 94% yield) as off-white solid. LCMS data: Calculated MH+ (160); Found 97% MH+ m/z (160), Rt = 1.44 mins.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,3-Triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EVOTEC NEUROSCIENCES GMBH; WO2009/95394; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics