Some common heterocyclic compound, 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C2H2N3Na
150 g (1 eq) of compound G was added to 1.5 L of DMF and added178 mg (5 eq) of sodium triazole and 38 ml of 1,3-dimethylpropylene urea (DMPU),And the mixture was stirred at 100 to 110 C for 24 hours.The reaction mixture was cooled to room temperature, 1.5 L of water was added to the reaction solution, and impurities were extracted with 400 ml of * 2 DCM. The organic phase was washed with 300 ml of 6NHCl extraction, hydrochloric acid aqueous solution with 100ml * 2DCM washing, separation of hydrochloric acid aqueous solution, temperature control below 30 50% NaOH adjusted PH = 8-9, extracted with 500ml * 2EA, combined EA, 300ml * 5 washing, 300mlBrine, brine, dried over Na2SO4 and concentrated to give a yellow oil. 200 ml of EA was added,Solution, dropping 800ml n-heptane solid wash, stirring at room temperature 3h, suction filtration, 200ml n-heptane washing, wasTo a white solid compound H of 86.9 g, Y = 68.5%, pur = 95.2%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41253-21-8, its application will become more common.
Reference:
Patent; Chongqing Weipeng Pharmaceutical Co., Ltd; Han, Gongchao; Zhou, Zhiliang; Zhou, Xingguo; Xiang, Yong; Xiang, Linling; Gong, Xue; (8 pag.)CN105440022; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics