Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 584-13-4, Name is 4H-1,2,4-Triazol-4-amine, molecular formula is , belongs to Triazoles compound. In a document, author is Kustov, Andrey, V, Recommanded Product: 4H-1,2,4-Triazol-4-amine.
Thermodynamics of transfer and partition of 3,5-diamino-1-phenyl-1,2,4-triazole in the 1-octanol/water biphasic system
In this paper, we focus for the first time on thermodynamics of transfer of 3,5-diamino-1-phenyl-1,2,4-triazole (DAPT) from water to liquid 1-octanol which is considered in pharmaceutical chemistry as an appropriate model of a lipid-like environment for studying a passive membrane transport of various drugs. The enthalpies of solution of DAPT have been determined calorimetrically in both solvents at 298.15, 308.15 and 328.15 K. The partition coefficients (P) have been obtained in the 1-octanol/water biphasic system at 298.15 and 328.15 K using a classical isothermic saturation method. Standard thermodynamic functions of DAPT transfer from water to a lipid-like phase have been calculated via the Gibbs-Helmholtz equation using the temperature dependence of the standard enthalpies of solution and the partition coefficient at the reference temperature of 298.15 K. We have found that the enthalpic term favours the solute transfer both at lower and elevated temperatures, whereas the entropic one contributes in the opposite manner. The free energy of transfer remains negative for all the temperature range studied indicating rather appreciable affinity of a potential drug towards a lipid-like environment. The comparison of the experimental and calculated P values indicates that our approach is able to predict with a good accuracy the behaviour of the 1,2,4-triazole derivatives for the physiological temperature range.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 584-13-4, in my other articles. Recommanded Product: 4H-1,2,4-Triazol-4-amine.