Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Recently I am researching about APP; TRANSPORT; SIGNALS; UBIQUITINATION; DEGRADATION; TRAFFICKING; MEMBRANE; INTERNALIZATION; LOCALIZATION; COMPONENTS, Saw an article supported by the Projekt DEAL; AFI (Alzheimer Forschung Initative e.V.); BioComp (Forschungsinitiative Rheinland-Pfalz); TU Nachwuchsring; DFG (Deutsche Forschungsgemeinschaft)German Research Foundation (DFG). Published in SPRINGER BASEL AG in BASEL ,Authors: Eggert, S; Gruebl, T; Rajender, R; Rupp, C; Sander, B; Heesch, A; Zimmermann, M; Hoepfner, S; Zentgraf, H; Kins, S. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine
Endocytosis of the amyloid precursor protein (APP) is critical for generation of beta-amyloid, aggregating in Alzheimer’s disease. APP endocytosis depending on the intracellular NPTY motif is well investigated, whereas involvement of the YTSI (also termed BaSS) motif remains controversial. Here, we show that APP lacking the YTSI motif (Delta YTSI) displays reduced localization to early endosomes and decreased internalization rates, similar to APP Delta NPTY. Additionally, we show that the YTSI-binding protein, PAT1a interacts with the Rab5 activator RME-6, as shown by several independent assays. Interestingly, knockdown of RME-6 decreased APP endocytosis, whereas overexpression increased the same. Similarly, APP Delta NPTY endocytosis was affected by PAT1a and RME-6 overexpression, whereas APP Delta YTSI internalization remained unchanged. Moreover, we could show that RME-6 mediated increase of APP endocytosis can be diminished upon knocking down PAT1a. Together, our data identify RME-6 as a novel player in APP endocytosis, involving the YTSI-binding protein PAT1a.
Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Eggert, S; Gruebl, T; Rajender, R; Rupp, C; Sander, B; Heesch, A; Zimmermann, M; Hoepfner, S; Zentgraf, H; Kins, S or send Email.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
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