The chemical industry reduces the impact on the environment during synthesis 6818-99-1, name is 3-Chloro-1,2,4-triazole, I believe this compound will play a more active role in future production and life. 6818-99-1
200 mg of intermediate 35, 60% sodium hydride(Oily) 37 mg, and DMF 2 mL,Under ice-cooling, 67 mg of 3-chloro-1H-1,2,4-triazole was added. After stirring for 2.5 hours under ice cooling,Saturated multilayer aqueous solution was added to the reaction mixture,And extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried over anhydrous sodium sulfate.The obtained organic layer was dried under reduced pressure.The obtained residue was subjected to silica gel chromatography,171 mg of the present invention compound 246 described below was obtained.
The chemical industry reduces the impact on the environment during synthesis 6818-99-1. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sumitomo Chemical; Ikari, Kaori; (123 pag.)JP2019/6686; (2019); A;,
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