7343-34-2, name is 3,5-Dimethyl-4H-1,2,4-triazole, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C4H7N3
General procedure: To a solution of 1-(3-chloropyridin-2-yl)piperidine-4-carboxylic acid (0.61 mmol) andamine/aniline (0.73 mmol, 1.2 eq.) in DMF (4 ml) was added TBTU, (alternatively HATU or EDCI)(0.92 mmol, 1.5 eq.) and diisopropyl ethylamine (1.8 mmol, 3.0 eq.). The reaction mixture wasstirred at room temperature until completion of the reaction. The reaction mixture was dilutedwith ethyl acetate and washed with 1N HCl, water and brine. The organic phase was dried oversodium sulfate, filtered and concentrated. The crude material was purified by columnchromatography or preparative HPLC (C18, acetonitrile/water gradient).
The synthetic route of 7343-34-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Schlapbach, Achim; Revesz, Laszlo; Pissot Soldermann, Carole; Zoller, Thomas; Regnier, Catherine H.; Bornancin, Frederic; Radimerski, Thomas; Blank, Jutta; Schuffenhauer, Ansgar; Renatus, Martin; Erbel, Paulus; Melkko, Samu; Heng, Richard; Simic, Oliver; Endres, Ralf; Wartmann, Markus; Quancard, Jean; Bioorganic and Medicinal Chemistry Letters; vol. 28; 12; (2018); p. 2153 – 2158;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics