Reference of 74205-82-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74205-82-6 name is (1H-1,2,4-Triazol-1-yl)methanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A mixture containing 25 ml of acetonitrile, two equivalents of (3,5-dimethyl-1H-pyrazol-1-yl) methanol (compound 2), and one equivalent of N,N-Diethyl-propanediamine was stirred at room temperature for 4 days. Next, the solvent was concentrated at a reduced pressure, washed with brine and dichloromethane. The organic solution was dried with MgSO4, and the solvent was concentrated at reduced pressure to yield compound 3 as light yellow oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1H-1,2,4-Triazol-1-yl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Bendaha, Hasnae; Yu, Lisa; Touzani, Rachid; Souane, Rachid; Giaever, Guri; Nislow, Corey; Boone, Charles; El Kadiri, Sghir; Brown, Grant W.; Bellaoui, Mohammed; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4117 – 4124;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics