Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, A new synthetic method of this compound is introduced below., category: Triazoles
5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid (11.94 gm, 0.058 moles) and DCM (15 ml) were charged in round bottom flask at room temperature. The reaction mixture was cooled to 0-5 C. and oxalyl chloride (5.07 mL, 0.058 moles) was added under inert atmosphere followed by the addition of DMF (1.18 mL, 0.0152 moles). The temperature of reaction mixture was raised to RT and stirred for 2 h. (R)-1-benzyl-5-methyl-1,4-diazepane (12 g, 0.058 moles, formula VII. DBT salt was neutralized with NaOH to obtain free base), triethyl amine (16.57 mL, 0.1176 moles) and DCM (500 mL) were taken in another RBF at 0-5 C. and stirred at room temperature for 2 h. The resulting mixture was slowly added to mixture containing triazole at 0-5 C. and stirred. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was diluted with water and extracted with DCM (2*7.5 mL). The combined organic layer was dried over Na2SO4 and concentrated under reduced pressure to give crude material. The obtained crude material was purified by column chromatography using silica gel (60-120 mesh), 2% MeOH-DCM as an eluent to give (R)-(4-benzyl-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (Formula IX, 18 g) as a brown color liquid. The obtained crude compound was used for the next step without any further purification.
The synthetic route of 956317-36-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DR. REDDY’S LABORATORIES LIMTED; IQBAL, Javed; DAHANUKAR, Vilas Hareshwar; ORUGANTI, Srinivas; KANDAGATLA, Bhaskar; (23 pag.)US2016/168138; (2016); A1;,
1,2,3-Triazole – Wikipedia,
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