Adding a certain compound to certain chemical reactions, such as: 288-88-0, name is 1H-1,2,4-Triazole, belongs to triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-88-0, Quality Control of 1H-1,2,4-Triazole
6.91 g (100 mmol) of triazole was added to a 250 mL three-necked flask equipped with a magnet.14.86g (107.5mmol)Potassium carbonate and 80 mL of DMSO,Add 5 drops of Aliquat336 dropwise with stirring.After heating to 90 C, maintain 5 min;Further, 12.9 mL of p-fluorobenzaldehyde (120 mmol) was slowly added dropwise to the flask.The reaction was stopped after stirring at 80 C for 24 h.Hot filtered,Pour the filtrate into 500 mL of ice water.Stir,There is a lot of solid precipitation,Let stand layering,Filtering,Obtained white flocculent solid 13.03g,The yield is 75.2%,
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,4-Triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Fuyang Normal College; Liu Jie; Miao Hui; Qiao Rui; Liu Zhaodi; (18 pag.)CN109206405; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics