Related Products of 6086-21-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6086-21-1 as follows.
Intermediate 291 -Methyl-1 H-1 ,2,4-triazole-5-carboxylic acid 1 -Methyl-1 H-1 ,2,4-triazole (1.19g) was dissolved in THF (15ml) and cooled to -78°C under nitrogen. A 1.6M solution of butyllithium in hexane (9.4ml) was added dropwise. The solution was stirred for 1.5h at -78°C, then the solution was treated with solid carbon dioxide (2g). After 30min at -78°C the solution was allowed to warm to RT and stirred overnight. The reaction was quenched with water (1 ml) and the solvent was decanted off. To the residue was added ethyl acetate (20ml) and water (20ml). The solvent was removed in vacuo and the residue was dried in a vacuum oven for 1 day (5O0C) to give the title compound (1.61g) as a white solid. LC/MS R1 0.46min m/z 126 [MH”]. Method A
According to the analysis of related databases, 6086-21-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/147188; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics