Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74733-90-7, name is 2-(4-Bromophenyl)-2H-1,2,3-triazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-(4-Bromophenyl)-2H-1,2,3-triazole
Step 3: 6-(4-(2H-1,2,3-triazol-2-yl)phenyl)-N-(1-((1-cyanocyclopropyl)carbamoyl)-4,4-difluorocyclohexyl)benzofuran-2-carboxamide To a 50 mL two-neck flask were added 2-(4-bromophenyl)-2H-1,2,3-triazole (42 mg, 0.18 mmol), N-(1-((1-cyanocyclopropyl)carbamoyl)-4,4-difluorocyclohexyl)-6-(4,4,5,5 -tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-2-carboxamide (80 mg, 0.15 mmol), toluene (6 mL) and ethanol (2 mL). Then Pd(Ph3P)4 (156 mg, 0.14 mmol) and potassium carbonate (43.5 mg, 0.31 mmol) were added. The resulting mixture was stirred at 90C for 3 h. After the reaction was completed, the mixture was cooled to rt, and poured into water (20 mL). The mixture was stirred vigously, then extracted with ethyl acetate (20 mL*3). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by silica-gel column chromatography (EtOAc:DCM=1:20, V/V) to give a white solid (45 mg, 54.43%). MS(ESI, pos.ion)m/z:531.4 (M+1); 1H NMR (400 MHz, DMSO-d6) delta 8.78 (s, 1H), 8.52 (s, 1H), 8.20-8.12 (m, 3H), 8.06 (s, 1H), 8.00 (d, J = 8.6 Hz, 2H), 7.92 (d, J = 8.2 Hz, 1H), 7.76 (d, J = 7.8 Hz, 2H), 2.22 (s, 3H), 2.02 (d, J = 25.0 Hz, 6H), 1.08 (s, 3H), 0.86 (s, 2H).
According to the analysis of related databases, 74733-90-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; WANG, Xiaojun; ZHOU, Pingjian; YANG, Chuanwen; HUANG, Changwei; XIONG, Shaohui; ZHANG, Yingjun; ZHANG, Jiancun; (139 pag.)EP3342765; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics