Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, A new synthetic method of this compound is introduced below., Computed Properties of C9H7N3O2
EXAMPLE H N-ethyl-N-(2-((4-(2-hvdroxypropan-2-yl)pyrim^ triazol-2-yl)benzamide Step 1 : tert-butyl (2-(2-(2H-1.2.3-triazol-2-yl)benzamido)ethyl)(methyl)carbamate (H-2) To a mixture of 2-(2H-l,2,3-triazol-2-yl)benzoic acid (2.37 g, 12.5 mmol), HATU (6.0 g, 0.0158 mol) in THF (40 mL) was added DIEA (5.5 g, 0.042 mol). The mixture was stirred at RT for 10 min, then teri-butyl(2-aminoethyl)(methyl)carbamate (1.8 g, 10.5 mmol) was added. The resulting mixture was stirred at RT for 16 h, then poured into water and extracted with EtOAc (100 mL). The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel (50% EtOAc in petroleum ether) to give the title compound H-2(2.6 g). LRMS m/z (M+H) 346.3 found, 346.2 required.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KIM, Ronald; KUDUK, Scott, D.; LIVERTON, Nigel; ZHUO, Gang; (116 pag.)WO2016/100161; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics