In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 138479-53-5, name is 2-[1,2,4]Triazol-1-yl-benzaldehyde belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-[1,2,4]Triazol-1-yl-benzaldehyde
A reaction mixture of 4-(2-amino-pyrimidin-5-yl)-N1-(l, l-dimethyl-propyl)-benzene-l,2- diamine (130 mg, 0.48 mmol), 2- 1,2,4-triazol- l-yl-benzaldehyde (110 mg, 0.64 mmol) and L-proline (5 mg) in MeOH (25 mL) is refluxed for 16 hours. The reaction mixture is allowed to cool to room temperature and is concentrated under reduced pressure. The residue is purified by silica gel flash column chromatography with 8% MeOH in CH2C12 as the eluent to afford 5-[l-(l, l-dimethyl-propyl)-2-(2-l,2,4-triazol- l-yl-phenyl)-lH- benzimidazol-5-yl]-pyrimidin-2-ylamine. LCMS (ESMS): m/z 425.20 (M++l)
The synthetic route of 138479-53-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; HAO, Ming-Hong; LIU, Weimin; LO, Ho-Yin; LOKE, Pui Leng; MAN, Chuk, Chui; MORWICK, Tina, Marie; NEMOTO, Peter, Allen; TAKAHASHI, Hidenori; TYE, Heather; WU, Lifen; WO2011/68821; (2011); A1;,
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