Electric Literature of 16681-70-2, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
[0622] (2S,4S)-4-Amino-5-biphenyl-4-yl-2-cyanomethylpentanoicacid ethyl ester (70 mg, 199 f.tmol) was combinedwith DMF (1 mL), HATU (76 mg, 199 flillOI), DIPEA (104f.LL, 596 f.tmol), and 3H-[1,2,3]triazole-4-carboxylic acid (22mg, 199 flillOI) and the mixture was stirred at room temperaturefor 20 minutes. The solvent was evaporated and the crudemixture was purified by normal phase chromatography(0-100% EtOAc/hexanes) to yield Compound 1 (60 mg).
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 1H-[1,2,3]Triazole-4-carboxylic acid.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics