74205-82-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 74205-82-6 as follows.
PREPARATION EXAMPLE A (COMPOUND NO. 15) 2-(4-Chloro-2-fluoro-5-ethoxycarbonylmethoxyphenyl)-4, 5,6,7-tetrahydro-2H-isoindole-1,3-dione (4.0 g, made substantially by the methods described in EP 0 083 055 A2) and KOH (85%, 2.1 g) in 50 ml ethanol were stirred at room temperature for 1 hour and then evaporated to dryness. To the residue was added 100 ml chloroform and 8 ml SOCl2. The reaction mixture was then heated to reflux for 2 hours. Potassium chloride was filtered and washed with fresh chloroform. The filtrate was evaporated to dryness. To the residue was added 50 ml chloroform and 1.5 g 1-hydroxymethyl-(1H)-1,2,4-triazole. The reaction mixture was then stirred at room temperature for 5 hours. Water was added to the mixture, the organic layer was separated and washed with water and brine, dried and concentrated. The residue was purified by silica gel column chromatography to give 2.1 g of 2-(4-chloro-2-fluoro-5-[(1,2,4-triazolylmethoxy)carbonylmethoxy]phenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione (Compound No. 15). M.P. 151-154 C.
According to the analysis of related databases, 74205-82-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Rohm and Haas Company; US6258751; (2001); B1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics