Recommanded Product: 61-82-5. In 2021.0 BIOORG MED CHEM LETT published article about FRUITING BODY; ACID; DERIVATIVES; CINNAMOMEA; APOPTOSIS; CELLS; EXTRACT in [Li, Bin; Kuang, Yi; Yi, Yang; Qiao, Xue; Liang, Lei; Ye, Min] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China; [Li, Bin] Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Minist Educ,Key Lab Bioact Subst & Resources Util, Beijing 100193, Peoples R China in 2021.0, Cited 25.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.
In order to discover potential antitumor agents from natural products, chemical modifications of ergostane-type triterpenoids from Antrodia camphorata yielded ten new compounds. They include nine C-26 amide derivatives of antcin G (1) and a methyl antcin B (4) derivative with hydroxyamino groups at C-3 and C-7. Chemical structures of the new compounds were elucidated by NMR and MS analyses. Furthermore, cytotoxicities of the triterpenoid derivatives were evaluated using four human cancer cell lines (HL60, U251, SW480, and MCF-7). As a result, 1a, 1g, and 4a exhibited potent cytotoxic activities against HL60, U251, and SW480 with IC50 values of 0.7 +/- 0.9, 2.9 +/- 1.3, and 2.2 +/- 0.6 mu M, respectively. Molecular docking indicates that 1a, 1g, and 4a have strong binding affinity with DNA topoisomerase II alpha (-9.3, -7.9, and -7.4 kcal/mol, respectively), and that they could be potent topoisomerase II alpha inhibitors.
Welcome to talk about 61-82-5, If you have any questions, you can contact Li, B; Kuang, Y; Yi, Y; Qiao, X; Liang, L; Ye, M or send Email.. Recommanded Product: 61-82-5
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics