Some scientific research about 1H-1,2,4-Triazol-5-amine

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Yuan, S; Feng, SQ; Li, AQ; Zuo, JH; Zhang, DQ; Xing, YJ; Xie, ZY; Yu, B; Liu, HM in [Yuan, Shuo; Feng, Si-Qi; Li, An-Qi; Zuo, Jia-Hui; Zhang, Dan-Qing; Xing, Yu-Jie; Yu, Bin; Liu, Hong-Min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Yuan, Shuo; Feng, Si-Qi; Li, An-Qi; Zuo, Jia-Hui; Zhang, Dan-Qing; Xing, Yu-Jie; Yu, Bin; Liu, Hong-Min] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Minist Educ, Zhengzhou 450001, Peoples R China; [Xie, Zhiyu] Xuchang Univ, Coll Chem & Mat Engn, 88 Bayi Rd, Xuchang 461000, Henan, Peoples R China published Design and synthesis of new indole containing biaryl derivatives as potent antiproliferative agents in 2021.0, Cited 26.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A new series of indole containing biaryl derivatives were designed and synthesized, and further biological evaluations of their antiproliferative activity against cancer cell lines (MGC-803 and TE-1 cells) were also conducted. Of these synthesized biaryls, compound 4-methyl-2-((5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl) methyl)quinazoline (23) performed as the most potent antiproliferative agent that inhibited cell viability of MGC-803 cells with an IC50 value of 8.28 mu M. In addition, investigation of mechanism exhibited that the compound 4-methyl-2-((5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)methyl)quinazoline (23) could inhibit the expression of c-Myc and glycolysis related proteins, decrease the ATP and lactate production, and further induce apoptosis by activating the AMP-activated protein kinase (AMPK) and p53 signaling pathways.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics