Category: triazoles. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Methylnicotinic acid, is researched, Molecular C7H7NO2, CAS is 3222-47-7, about Functionalisation of esters via 1,3-chelation using NaOtBu: mechanistic investigations and synthetic applications. Author is Yang, Hye Sung; Macha, Lingamurthy; Ha, Hyun-Joon; Yang, Jung Woon.
For the first time, both 1,3-chelation and the formation of a tetrahedral intermediate were confirmed as the key factors for the unusual nucleophilic behavior of a metal t-butoxide in a transesterification reaction. NMR and real-time IR spectroscopies and deuterium-labeling experiments were used for the mechanistic investigation. Based on a pivotal point in the mechanistic understanding of the action of t-butoxide anion, several uncovering reactions such as direct access to value-added chiral α-amino acid t-Bu ester with almost complete retention of optical purity via elaborative transesterification, non-hydrolytic deesterification of esters, and selective bond cleavage of 3-benzoyloxazolidin-2-ones, were successfully achieved.
This literature about this compound(3222-47-7)Category: triazoleshas given us a lot of inspiration, and I hope that the research on this compound(6-Methylnicotinic acid) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics