Category: Triazoles. In 2020.0 J INORG BIOCHEM published article about METAL-COMPLEXES; PLATINUM(II) COMPLEXES; ANTIBACTERIAL ACTIVITY; SILVER NANOPARTICLES; CRYSTAL-STRUCTURES; IN-VITRO; CARBOXYLATES; DERIVATIVES; SPECTROSCOPY; HETEROCYCLES in [Fandzloch, Marzena] PAS, Inst Low Temp & Struct Res, Okolna 2, PL-50422 Wroclaw, Poland; [Augustyniak, Adam W.] Univ Wroclaw, Fac Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland; [Dobrzanska, Liliana] Nicolaus Copernicus Univ Torun, Fac Chem, Gagarina 7, PL-87100 Torun, Poland; [Jedrzejewski, Tomasz] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Immunol, Lwowska 1, PL-87100 Torun, Poland; [Sitkowski, Jerzy] Natl Inst Med, Chelmska 30-34, PL-00725 Warsaw, Poland; [Sitkowski, Jerzy] Polish Acad Sci, Inst Organ Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland; [Wypij, Magdalena; Golinska, Patrycja] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Microbiol, Lwowska 1, PL-87100 Torun, Poland in 2020.0, Cited 82.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.
Five novel rhodium(II) complexes of general formula [Rh-2(mu-OOCCH3)(4)L-2], where L is a triazolopyrimidine derivative, in particular dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (dmtp) for (1), 5,7-diethyl-1,2,4-triazolo[1,5a]pyrimidine (detp) for (2), 7-isobutyl-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine (ibmtp) for (3), 7-hydroxy-5methyl-1,2,4-triazolo[1,5-a]pyrimidine (HmtpO) for (4) and 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp) for (5) are reported. These first representatives of paddle-wheel dirhodium complexes with triazolopyrimidines have been characterized by IR and NMR spectroscopy as well as by single-crystal X-ray diffraction studies. Three of the new complexes (1), (2) and (5) were thoroughly screened in vitro for their cytotoxicity against human breast cancer cell line MCF-7 and L929 murine fibroblast cells. Favorably, they show significantly less effective inhibition on the cell growth of L929 than cisplatin under identical conditions. Complexes (1) and (5) display moderate cytotoxic activity (IC50 = 16.3-21.5 mu M) against MCF-7 cells which is induced via reactive oxygen species-independent pathways. Extensive studies of rhodium complexes (1), (2) and (5) against microorganisms have shown that the tested compounds exhibit antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) while (5) significantly inhibited the growth of Malassezia furfur. The highest antibacterial, and antifungal activity, was observed for (5).
Welcome to talk about 61-82-5, If you have any questions, you can contact Fandzloch, M; Augustyniak, AW; Dobrzanska, L; Jedrzejewski, T; Sitkowski, J; Wypij, M; Golinska, P or send Email.. Category: Triazoles
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics